Please read medical disclaimer at the end of the article, and consult your personal health care provider prior to acting upon any information provided in this article, protocol, or website.

Discussion

Cervical dysplasia is caused by Human Papilloma Virus (HPV). Human Papilloma Virus is one of the most important carcinogens in humans. In the United States, over 33,000 cases of HPV-related cancers are diagnosed annually.(1) HPV is the cause of almost all cervical cancers, as well as the majority of vaginal, vulvar, anal, and even penile cancer.(2) It is also a major contributor to oral & throat cancer, as what most famously happened to the actor, Michael Douglas.

HPV is the cause of cervical dysplasia, or abnormal cellular growth. A precancerous condition known as Cervical Intraepithelial Neoplasia (CIN), has gradations of severity, from mild, or low-grade (CIN 1), to moderate, or high-grade (CIN 2) and severe (CIN 3). It may then worsen to carcinoma-in-situ, which is borderline cervical cancer. From there, it is only one-cell layer away from being cervical cancer.

Dysplasia means “abnormal growth.” The cells are abnormal. There is very little difference between a cancer cell, and a dysplastic cell, or an “abnormal cell.” Cervical dysplastic cells are essentially cancerous cells, though we refer to them as pre-cancerous cells. Despite this, cervical dysplasia is not considered cervical cancer because of the depth of penetration of the abnormal cells. Think of layers of the epidermis. There are several layers of cells of the epidermis down to the basement layer, below which is the dermis with collagen fibers and blood vessels, etc. The same with the cervix. How many layers of cells the abnormal cells fill up determines the stage of dysplasia, along with the abnormality of the cells themselves.

If the dysplastic cells cross below the basal layer, or basement membrane, of the cervix, then cancer is diagnosed, and the outcome and treatment is quite different than for just cervical dysplasia.

How rapidly cervical dysplasia progresses into cervical cancer depends upon the particular viral strain of HPV present, as well as the state of one’s immune system. A weakened immune system will be unable to inhibit the virus, let alone be able to destroy developing cancerous cells.

Human Papilloma Virus is Ubiquitous

In my gynecological practice I saw abnormal pap smears and/or cervical dysplasia multiple times per week. Every day, I had multiple patients who had a history of abnormal Pap smears due to HPV. It is truly a ubiquitous infection, as are hundreds of other viruses that we as humans contract and carry throughout life. The vast majority of these viruses are suppressed due to an intact immune system; which is why AIDS is such a devastating disease, as it allows the many dormant viruses to replicate and express themselves as active diseases.

Human Papilloma Virus is transmitted sexually, which unfortunately caused some of my patients to feel embarrassed and unnecessarily defend their reputation to me. One particular patient was indignant that she had “a sexually-transmitted disease,” stating that she had only ever had sex with her husband! I reassured her that HPV is so ubiquitous that it does not require multiple sexual partners to acquire, and can be acquired from a single sexual encounter.

Human Papilloma Virus (HPV) is transmitted through genital-to-genital, and genital-to-mouth sexual contact. A person will not be infected with HPV if there is never any sexual contact. But, even one sexual partner provides a near 50% chance of acquiring HPV.(3) The odds of being infected with HPV go up with each new sexual partner, or with the more sexual partners their partner has ever had.

To emphasize, even if neither person in a couple were not ever promiscuous, as long as at least one of them had at least one other sexual partner at some point in their life, it is enough to acquire HPV. HPV is so common that all women are recommended to be routinely screened with Pap smears, and being diagnosed with HPV or cervical dysplasia is nothing to ever be embarrassed about.

There are over 100 strains, or sub-types of HPV, some more virulent than others; and it is a random occurrence as to which of the many HPV strains a person contracts. The various strains of HPV are identified by the virus’s DNA, with HPV strains 16 and 18 being associated with 70% of cervical cancers. Other high-risk HPV viruses include 31, 33, 45, 52, and 58. HPV sub-types 6 and 11 are associated with 90% of genital warts. A person can be infected with several strains of HPV simultaneously, which is why a person with condyloma acuminata is considered at increased risk of cervical and vulvar cancer.  (And penile cancer in men with a history of genital warts.)

HPV Vaccination

There are now three vaccines against HPV on the market, and are recommended to both young virginal teenage, or even pre-teen, boys and girls. The HPV screening, and vaccinations are considered effective in reducing HPV infection from many sub-types, especially when given prior to the onset of sexual activity.(4)

According to the CDC, all three HPV vaccines, Gardasil 9, Gardasil, and Cervarix are safe, effective, and recommended for all prepubescent children. HOWEVER, contrary to “settled science,” and the revelations of research fraud over the safety of vaccinations, in January 2016, the American College of Pediatricians released a statement warning against the dangers of Gardasil, the first vaccine on the market. (5)

One of the many concerns over HPV vaccines is uncommon complication of ovarian dysfunction; which is ovarian failure, or menopause. The result is anovulation, and therefore infertility. Gardasil contains Polysorbate 80, which was known to cause ‘adverse reproductive effects’ in animal studies. This uncommon side effect is often masked by birth control pills, as without them a young woman would easily realize the absence of periods.

In April 2014, the French medical doctor, Bernard Dalbergue, who is a former pharmaceutical industry physician with Merck, the manufacturer of Gardasil, stated, “I predict that Gardasil will become the greatest medical scandal of all times because at some point in time, the evidence will add up to prove that this vaccine, technical and scientific feat that it may be, has absolutely no effect on cervical cancer and that all the very many adverse effects which destroy lives and even kill, and serve no other purpose than to generate profit for the manufacturers.”(6)

After obtaining a series of emails via a Freedom of Information request, in January 2016, Sin Hang Lee, M.D., director of the Milford Molecular Diagnostics Laboratory in Connecticut, essentially proved Dr. Dalbergue’s prediction correct in a report he sent to the CDC, the W.H.O., the Ministry of Health in Japan, and others, with documentation of “scientific misconduct” among the world’s leading health organizations tasked with providing vaccine safety, by deliberately misleading Japanese health authorities on the safety of HPV vaccines.(7)

In 2012, Dr. Lee, a practicing pathologist for over 50 years, and Director of Milford Molecular Diagnostics, Milford, Connecticut, was called to examine the death of Jasmine Renata in New Zealand, who died 6 months after receiving the Gardasil vaccine.

Dr. Lee wrote: “The finding of these foreign DNA fragments in the post-mortem samples six months after vaccination indicates that some of the residual DNA fragments from the viral gene or plasmid injected with Gardasil have been protected from degradation in the form of DNA-aluminum complexes in the macrophages; or via integration into the human genome.

Viral and plasmid DNA fragments are known to activate macrophages, causing them to release tumor necrosis factor, a myocardial depressant which can induce lethal shock in animals and humans.”(8)

Due to laws passed by congressmen and senators, in the United States Merck, the maker of Gardasil, gets a free pass on harm caused by the HPV vaccine, as they cannot be sued for damages, nor be held legally liable; and reporters who attempt to release unfavorable stories about the vaccine are stifled or fired. The very health institutions, the bastions of authorities we turn to for health information and recommendations, such as the CDC and National Institute of Health (NIH), actually receive royalties from vaccine sales. And, you can guess HOW such laws to protect the pharmaceutical giants got passed. Do you even question whom our congress serves and protects?

Young women are losing their fertility, and both young women and men are also dying from the HPV vaccine. To see a partial list, and faces of some of the victims from around the world, whose lives were cut short, check out SaneVax, Inc.’s website (click here), an organization that is dedicated to warning parents about the dangers of the HPV vaccine.

I personally know two families who lost their young daughters to the HPV vaccine. Their healthy young daughters go in for the recommended vaccine, and within days in one case, to a few weeks in the other, they are holding funerals.

So, are we really protecting our youth from cervical cancer? How many women were lost to cervical cancer (caused by HPV) prior to June 2006, when Gardasil was first introduced?

In 2005, the number of new cervical cancer cases in the United States was 10,370. The incidence rates had steadily declined over the past several decades in both white and black women as Pap screening had become more prevalent, detecting precancerous (cervical dysplasia) lesions, and treating them before they advanced to invasive cancer.(9)

As for deaths, an estimated 3,710 women died from cervical cancer, a number that has also steadily declined with more prevalent early detection via Pap smears and biopsies, followed up by LEEP or cone biopsies. Most deaths occurred among women who did not get regular Pap screening, and/or didn’t follow up with treatment of abnormal findings.

In summary, prior to HPV vaccines, in 2005 in the United States there were 10,370 new cases of cervical cancer, and 3,710 deaths. Let’s compare that to 8 years post-introduction of the HPV vaccine. According the CDC, in 2013 (the most recent statistics available at the time of the writing of this article), the incidence of cervical cancer was 11,955, and deaths were 4,217; essentially, unchanged at best, and possibly worse!

I realize that not all young people are vaccinated, especially with only half of the doctors in the U.S. recommending HPV vaccinations, and the numbers from 2005 to 2013 is not a fair comparison of the effectiveness of the vaccine, …so, what is the option? To have ALL young children vaccinated against HPV, and then see what the incidence of cervical cancer is? Yes, that is theoretically possible, and it may cut the incidence of cancer considerably, but at what cost to human life and sky-rocketing infertility rates? Are we going to lose our young sons and daughters to the vaccine in order to save them? And, those who don’t die, will they be infertile, or have other side-effects of the HPV vaccine? It makes one almost believe in a depopulation conspiracy agenda for profit. It would only make sense to vaccinate if it helped without causing harm, the first rule of medicine.

The possible documented side effects of Gardasil HPV vaccine include: seizures, strokes, dizziness, chronic fatigue, weakness, headaches, stomach pains, vomiting, Guillain-Barre syndrome, joint pain, autoimmune disease, chest pains, hair loss, appetite loss, personality changes, insomnia, tremors, shortness of breath, heart problems, lasting paralysis, itching, rashes, swelling, aching muscles, pelvic pain, nerve pain, menstrual cycle changes, premature ovarian failure (infertility), fainting, swollen lymph nodes, night sweats, nausea, temporary vision and hearing loss, and death.

Am I overstating the risks, and causing undue fear? No, not if it is your child!  So, what are the options? Sexual abstinence, or life-long sexual partnership between two virgins? Not likely for the majority of the population; not these days, anyway.

I would suggest routine annual Pap smears, and treatment as necessary. Do you swab for HPV strains? How will that change anything, other than to make sure you continue to get routine Pap smears, and treat as necessary? I would suggest putting your children, your teenagers, and yourselves, on a high-quality nutritional supplement program, every day for life. After you read the benefits of the micronutrients in inhibiting HPV and preventing the progression of cervical dysplasia below, I think you would agree with this sensible suggestion.

Other risk factors for cervical cancer besides HPV infection, are smoking, suppressed immune system, increased stress, corticosteroids, and HIV infection. The last three (stress, steroids, and HIV infection, are all just reasons for a suppressed immune system).

Charise’s Experience with Cervical Dysplasia and Supplementation

In my ob/gyn practice, I recommended generous doses of vitamins, minerals, omega-3 fatty acids, and a myriad of antioxidants, especially grape seed extract, to my patients with HPV and cervical dysplasia.  Since then, I have suggested additional antioxidant micronutrients to inhibit HPV, and reverse cervical dysplasia. Medical studies support my decisions and protocols, and what I have witnessed, and still hear back from many women around the globe, further confirm that these protocols are indeed working. High-quality, pure and potent, bio-available nutritional supplements make a huge difference in preventing and reversing cervical dysplasia (and cervical cancer).

The most impressive case of reversal of cervical dysplasia that I witnessed, was my patient Charise. She was 27 years old at the time, a non-smoker, who had already had severe cervical dysplasia (CIN 3) prior to coming to me. She had already had a LEEP cone biopsy one year before I first saw her as a patient, and now was seeing me for follow up Pap smear. Unfortunately, her Pap smear showed severe dysplasia, so I appropriately followed that up with a colposcopy and biopsy.

Sadly, those biopsies revealed a worsened condition. The cervical dysplasia had progressed to carcinoma-in-situ. This is borderline cervical cancer, or localized cervical cancer; essentially one cell layer away from being invasive cervical cancer.

She was obviously very discouraged with this news, as her situation had only worsened over the past 5 years. I told her needed to do another LEEP cone biopsy to both remove the carcinoma-in-situ (dysplastic cells), and to assess as to whether the “precancerous cells” have invaded the cervical basement membrane, and has become cancer.

If the LEEP cone biopsy I was scheduling were to come back as invasive cervical cancer, she would possibly be looking at a radical hysterectomy and radiation therapy. In near tears, she said, “Dr. McNamara, I’m 27 years old! I’m not married, and I want to have children one day, I can’t have a hysterectomy. Isn’t there anything I can do?”

I explained to her that smoking and HPV increases the risk of cervical cancer, and although she didn’t smoke, I wanted to give her what I considered “anti-smoking therapy,” and something that inhibits HPV, and helps destroy dysplastic cells. I told her about my supplement protocol, and how antioxidants, particularly grape seed extract inhibits HPV and kill dysplastic and cancerous cells. So I recommended my protocol, with high-dose grape seed extract.

It has been shown over and over again that oxidative stress, or damage, whether by smoking, physical or emotional stress, or other factors, suppresses the immune system, and causes cervical cells to be vulnerable to HPV infection and expression, to where they turn dysplastic.(10) Interestingly, not only do antioxidants protect healthy cells from damage, they cause abnormal cells (dysplastic or cancerous cells) to self-destruct (apoptosis), via several mechanisms.

Desperate for hope, Charise started my protocol immediately, including a triple dose of grape seed extract. However, she couldn’t do the LEEP cone biopsy as soon as I had asked. After 6 weeks of being on the supplement protocol, she finally had the LEEP procedure. She and I both nervously awaited the pathology report. I was concerned that her delay might have caused it to progress to cervical cancer. At the same time, I was hoping that the supplement protocol might have down-graded the carcinoma-in-situ back to at least severe dysplasia.

Several days later, the report revealed, “negative: no evidence of neoplasia.” In other words, not only was there no cancer, there was no dysplasia. It was 100% normal tissue! I never conceived of this big of a change in 6 weeks from the supplement protocol. This blew me away, and changed my thinking forever. Of course, Charise was thrilled.

Even the pathologist who microscopically examined the tissue called to ask why I did a LEEP cone biopsy on a “normal cervix.” It was interesting to hear his reaction while on the phone with him, as he looked her records. He had examined the prior biopsy tissue 6 weeks earlier showing carcinoma-in-situ. He was confused, saying, “I don’t know what happened. She certainly had significant pathology 6 weeks ago, but she does not have it now.”

Charise needed to have repeat Pap smears to make sure the dysplasia did not return, as it had consistently for the prior 5 years. She remained on the supplement protocol, and over the following 2 years that she remained my patient, all of her follow-up Pap smears remained normal. She eventually moved away, and I don’t have any knowledge of her current situation.

I have had many other patients with similar significant results, even one with carcinoma-in-situ, whom I was able to relate Charise’s story. That patient had a similar result. Every patient of mine who had cervical dysplasia who followed my supplement protocol had complete resolution of dysplasia. It works because the supplements are pure, potent, and bio-available.  (A few patients had a recurrence of cervical dysplasia, but those cases were only among patients who stopped the supplement protocol.)

Regular, over-the-counter supplements lack the potency and purity to ensure such results as I was witnessing. How do I know? I have studied it, and I had many patients with cervical dysplasia using other brands without satisfactory results. Despite taking what they thought were quality vitamins, they experienced recurrent cervical dysplasia.

Nutritional Supplements Destroy Dysplasia

Besides a foundation of quality vitamins and minerals, I suggest a generous and safe dose of grape seed extract as a major component of my protocols. Grape seed extract is a class of polyphenol antioxidants known as proanthocyanidins. Polyphenols are powerful micronutrients that help inhibit the development of chronic diseases, in part due to their powerful antioxidant capabilities.(11)

Polyphenols (including grape seed extract) exert numerous beneficial effects upon healthy cells, and destructive effects on abnormal (dysplastic and cancerous) cells, as well as on bacteria, viruses, and fungi. Grape seed extract works best when combined with vitamin C, as the two work synergistically, with increased effectiveness against bacteria, viruses, and chronic illnesses.(12 – 18)

Grape seed extract and resveratrol, both derived from the red grape, provide benefits in protecting against both cancer development and progression by inhibiting cancer growth, and inducing cancer cell death, a process known as apoptosis.(19 – 21) Anything that helps inhibit or destroy cancer cells, will inhibit or destroy dysplastic (dysplasia) cells, as precancerous cells are essentially cancerous cells.

There is no known toxic dose to grape seed extract. The only real side-effect to be aware of is a possible osmotic diarrhea if one were to take a high dose (>  500 mg) all at one time, because the intestines can only absorb so much at any given time. That is why it is best to spread out dosages of most supplements throughout the day. Not only does that allow better absorption, but it allows for sustained blood levels and all-day nourishment and antioxidant protection.

Studies even prior to 1997 were reporting the many benefits of grape seed extract, or oligo-proanthocyanidins (OPC), in suppressing HPV, dysplasia, cervical cancer, and the induction of apoptosis (self-destruction of cancer cells). Grape seed extract targets a mechanism within the mitochondria of cancer cells, that disrupts the production of the all-important energy molecule, ATP.  Mitochondria then release a chemical that triggers the cancer cells to implode and undergo autophagy and apoptosis.(22) Grape seed extract induces self-destruction (apoptosis) of cervical cancer cells, by disrupting the mitochondria in cancer cells, while protecting the function of healthy cells.(23)

For any cell to duplicate, DNA is transcribed into RNA, which codes for protein synthesis. There programmed DNA sequences for cancer called oncogenes, and oncomirs are the RNA counterparts.

Oncomirs are microRNAs (miRNA) associated with development of cancer and malignancies. Stopping oncomirs is one way to stop some cancers. Oncomirs have become a target for some cancer treatments. It is also one of the several ways that grape seed extract inhibits dysplasia and cancer development.(24)

Studies have revealed grape seed extract and various other phenol antioxidants’ ability to suppress HPV in both cervical cells and in oral squamous cells.(25, 26)

Resveratrol comes from the skin and pulp of the red grape, and perfectly complements grape seed extract for reducing cardiovascular disease, as well as inhibiting HPV, preventing cervical dysplasia, and of course, prevention and adjunctive treatment of cervical cancer. As with grape seed extract, resveratrol has been shown to induce autophagy and apoptosis of cervical cancer cells.(27) (The foundational vitamin-antioxidant supplement I suggest in the protocol, provides resveratrol, along with many other beneficial synergistic micronutrients to inhibit and reverse cervical dysplasia.)

In 2009, a study conducted in Hawaii among 122 women with persistent HPV infection within the cervix, sought to determine the effects of vitamin, mineral, and antioxidant blood levels have on the clearance of HPV infection from the cervix. The researchers found that there was a correlation between certain micronutrients and HPV clearance. Those women with the highest blood levels of zeaxanthin, lutein, cryptoxanthin, lycopene, beta carotene, total carotenoids, and tocopherol (vitamin E), were able to clear HPV infection much faster than those women with lower levels of the micronutrients.(28)

Several of the above named micronutrients are provided within a high-quality vision support supplement, as well as by the high-quality vitamin-antioxidant supplement suggested within my protocols. Therefore, by following my protocols, one would be getting a very broad spectrum of potent and effective micronutrients, all of which will help inhibit and reverse cervical dysplasia, as well as inhibit and destroy cervical cancer cells, among the many other health benefits that would come with long-term use. For those undergoing cancer treatments, they can greatly benefit regarding energy and support of the the immune system.

Luteolin, not to be confused with lutein, is a phenol flavonoid antioxidant found in olive fruit extract. Luteolin has been found to suppress replication of the Human Papilloma Virus by binding to a viral protein (E6) that is necessary for viral replication.(29, 30)

Micronutrients within green tea extract inhibit HPV-16-induced angiogenesis (blood vessel growth for feeding abnormal cells). HPV-16 is one of the most virulent of the HPV viral strains, causing cervical dysplasia and cancer.(31) Angiogenesis is the “creation of blood vessels,” which is needed for cancer progression. For cancer cells to grow and spread, they require a rich blood supply. Cancer cells signal the creation of new blood vessels, which is what angiogenesis means. Angiogenesis is a critical component for cancer growth and invasion. Many micronutrients, including green tea extract, olive extract, grape seed extract, resveratrol, and turmeric extract, all suppress angiogenesis, and therefore inhibit the invasion and spread of cancer.

Like grape seed extract and resveratrol, green tea extract also induces apoptosis (self-destruction) of cells infected with HPV, meaning dysplastic and cancerous cells.(32) It also suppresses the HPV-viral binding protein E7.

Quercetin, a bioflavonoid antioxidant provided in broccoli extract, suppresses the expression of both E6 and E7 HPV viral proteins, preventing HPV-16 infected cells from replicating and progressing into dysplasia, and dysplastic cells from progressing into cancer, and prevents cancer cells from replicating.(33)

A high-quality ‘liver support’ supplement that I suggest in my protocol, along with a high-quality vitamin-antioxidant complex, provides many of the micronutrients mentioned above, such as turmeric extract (curcumin), olive extract, green tea extract, quercetin, resveratrol, as well, as alpha lipoic acid, N-acetyl-L-cysteine, and many others.

Beta Glucans (Derived from Mushrooms and Baker’s Yeast)

Beta glucans are fiber polysaccharide micronutrients derived from the cell membranes of the Reishi and Shiitake mushrooms, as well as from baker’s yeast extract (Saccharomyces cerevisiae). Beta glucans have powerful immuno-modulating properties; which means, they activate and support normal functions of the immune system. The immune system is key in preventing and destroying dysplasia and cancer cells, let alone bacteria, viruses, and fungi.

Beta glucan polysaccharides do not breakdown in the gut, and therefore do not have any impact on blood glucose levels, nor provide any effective calories. As a side-benefit, beta glucans act as prebiotics for digestive bacteria, improving the state of the microbiome (gut flora).

Beta glucans’ main benefits are that they exert antioxidant, anti-inflammatory, and immuno-modulating activities. Within the intestinal wall, beta glucans stimulate the white blood cells (macrophages) of the immune system to aggressively go after foreign invaders, such as bacteria, to prevent them from entering the bloodstream.

Beta glucan polysaccharides are quite impressive micronutrients; not only for their anti-microbial, anti-viral, anti-fungal effects, and anti-cancer effects, all due to activation of various immune system pathways, but if that weren’t enough, they also demonstrate anti-diabetic, anti-obesity and anti-depression properties.(34)

Beta glucans distinct molecular structure allows them to bind to cell membrane receptors on white blood cells, including macrophages, natural killer cells, and T lymphocytes, to aggressively attack and destroy many types of abnormal cells, among them, cervical, lung, and breast cancer cells.(35, 36)

The same micronutrients that inhibit cervical dysplasia and cervical cancer, fortunately also help reduce the risk of other cancers, let alone heart disease, stroke, diabetes, arthritis, macular degeneration, dementia, wrinkles, and much more.

Macrophages are white blood cells that gobble up and “digest” bacteria, dysplastic, and cancerous cells, whereas natural killer cells are white blood cells that destroy, bacteria, dysplastic, and cancerous cells by triggering the release of cytokines, signaling hormone-like chemicals that either disrupt their cell membranes and/or induce apoptosis (self-destruction) of the abnormal cells.

Beta glucans activate all types of white blood cells to act via their respective mechanisms, and thereby prevent and reverse dysplasia and cancerous cells. Beta glucans are even able to assist in cancer therapies, such as in cases of advanced breast cancer, where white blood cells (monocytes) are usually suppressed.(37, 38) An animal study showed that beta glucan supplementation even has a strong anti-cancer effect in reducing melanoma, and improving survival rates in such a tough cancer.(39)

Beta glucans work synergistically with other supplements, that is, they work better together to kill cancer cells than any of the micronutrients would individually. Some of the micronutrients shown to work synergistically with beta glucans, are resveratrol, and vitamin C; but there is no reason all other antioxidants, such as curcumin (turmeric extract), olive extract, green tea extract, quercetin, grape seed extract, N-acetyl-L-cysteine, etc., would not also work synergistically with beta glucans.(40)

Beta glucans trigger the adaptive immune system, by activating cytotoxic T lymphocytes, which bind to complement factors and antibodies, which in turn attach to, and ‘target’ cancer cells.

The most significant thing about beta glucans is, that they activate the immune response when needed to defend the body, while at the same time do not cause an abnormal “over-reaction,” as is seen with autoimmune disorders.  (A word of caution– until we have further clarification from medical studies, those with autoimmune disorders would be wise to hold off on taking a beta glucan supplement, just in case it might cause a flare up. It may not, but we don’t quite know yet. I have heard it both ways.)

Numerous micronutrients collectively work to inhibit invasion and metastases of cancer in the various ways. For example, selenium works synergistically with beta glucans to help destroy bacteria, viruses, fungi, dysplatic and cancer cells.(41) (By the way, selenium is provided in the foundational high-quality chelated mineral supplement listed in my protocol.)

Even for those not dealing with cervical dysplasia or cervical cancer, beta glucans are not a bad idea to take routinely for life, as they help ward off colds and flu’s, boost mood, and help reduce the risk of developing all other cancers.

Curcumin (Turmeric Extract)

Curcumin is a polyphenolic micronutrient extracted from the spice, turmeric.  It holds a mixture of strong bioactive molecules known as cucurminoids, that have the ability to inhibit dysplasia, cancers, and tumors at all stages of development; including initiation, progression, invasion, and metastases.

Curcumin effectively inhibits the cell cycle and growth of dysplastic and cancerous cells. It induces apoptosis (self-destruction) of cervical dysplasia and cancer cells, in part by modulating entities such as miRNAs (oncomirs), transcription factors, and proteins associated with carcinogenesis, and damaging the DNA of cancer cells.(42) Curcumin has shown an anticancer effect against many cancers thus far, including, but not limited to, colon, cervical, uterine, ovarian, breast, prostate, head and neck, pulmonary, oral, esophageal, gastric, pancreatic, bladder, and bone cancers.(43) Even more than beta glucans, curcumin’s benefits extend well beyond its anti-cancer effects. Curcumin benefits the heart, arteries, liver, joints, brain, kidneys, bladder, breasts, prostate, intestines, and helps prevent and reverse diabetes.

Curcumin has been extensively studied for its inhibitory effect on HPV infection, cervical dysplasia, as well as on primary and malignant cervical cancers. Curcumin has been shown to have preventive and anti-cancer effects against both HPV-related and non-HPV-related cervical cancers.(44, 45) Curcumin is able to counter the cell-signaling effects on cervical cells triggered by smoking and estrogen, which are factors in women who experience persistent HPV infections, dysplasia, and cervical cancer.

One of several mechanisms by which curcumin exerts its anti-cancer effect on cervical dysplasia and cancer is to induce apoptosis (self-destruction) by causing DNA damage and disruption.(46) But curcumin is poorly absorbed in the intestine, and at high doses it can cause gastrointestinal discomfort (gas, bloating, diarrhea). This is why curcumin is best provided as nano particles encased in liposomes, making it highly absorbable and bio-available, allowing for biological effects at relatively reduced doses, virtually eliminating gastrointestinal side-effects.

Curcumin exerts powerful anti-cancer effects.  However, when combined with other micronutrients, such as resveratrol derived from the red grape, and epicatechin gallate, extracted from green tea, each with their own anti-cancer effects, the combination has a synergistic anti-dysplasia and anti-cancer effect that is more powerful in killing dysplastic and cancer cells than any of them individually. When curcumin is combined with green tea extract, and/or resveratrol, it not only suppresses HPV, it eliminates HPV dysplasia and cancer cells, and it inhibits cervical cancer cell progression more effectively than by curcumin alone.(47)

Melatonin Should Not Be Forgotten

Melatonin is a hormone in the brain, used to regulate circadian rhythms (sleep-wake cycles).  Melatonin is also a powerful antioxidant, which is effective throughout the body. It has been used for many years in cancer treatments to enhance the effectiveness of some cancer therapies.

Although as an antioxidant, melatonin protects healthy cells, paradoxically, it acts as a pro-oxidant, killing dysplastic and cancer cells. It does so by interfering with mitochondrial function of dysplastic and cancerous cells, causing mitochondrial damage, and the release cytochrome C. Through a cascade of cellular events, autophagy and apoptosis (self-destruction) of cancerous cells ensues.(48)  Melatonin appears to not only promote apoptosis of cancerous cells, it also has been shown to inhibit the proliferation and invasion of ovarian, endometrial, breast, prostate and cervical cancers. Melatonin inhibits angiogenesis, effectively cutting off a would-be blood supply for a potential invasive cancer.

Melatonin has been shown to enhance tumor necrosis factor-α (TNF-α) immunotherapy, inhibiting progression of dysplasia and cervical cancer cells.(49)  Melatonin was found to enhance mitochondrial death, and inhibit mitophagy, triggering apoptosis of dysplasia and cancerous cells.

Conclusion

A wide array of safe and effective micronutrients, such as vitamins, minerals, omega-3 fatty acids (fish oil), and various antioxidants, are beneficial for whole body, life-long health, of every cell of every organ, for everyone. For women faced with cervical dysplasia and/or cervical cancer, daily supplementation with broad spectrum, high-quality micronutrients appears quite critical. It is also important for preventing and reversing cervical dysplasia, let alone cancer. Supplements help maintain energy and support a strong immune system, which is critical for preventing abnormal Pap smears, such as cervical dysplasia, let alone all other cancers.

After witnessing many women, at almost every stage of HPV-related cervical disease, from cervical dysplasia, carcinoma-in-situ, and invasive cervical cancer, do very well on my supplement protocols, I think adding these protocols to traditional medical treatments for abnormal Pap smears should be the new standard of care, and considered by every woman faced with dysplasia.

Protocol for HPV and Cervical Dysplasia

Even though I have listed the below protocols for mild dysplasia (CIN-1), moderate dysplasia (CIN-2), severe dysplasia (CIN-3), and carcinoma-in-situ, a person with a low-grade dysplasia (mild), can take the protocol for carcinoma-in-situ if they wish, as it will only be of benefit. It will never be “too much.” The only downside is the additional cost.

Please read medical disclaimer below, and consult your personal health care provider prior to acting upon any information provided in this article, protocol, or website.

Minimal Protocol for Cervical Dysplasia (CIN-1)

Basic Protocol for Cervical Dysplasia (CIN- 1 or 2)

Average Protocol for Severe Cervical Dysplasia (CIN-2 or 3)

Advanced Protocol for Severe Dysplasia (CIN-3) and Carcinoma-In-Situ

• AM: With, or after breakfast
• Noon: At lunchtime with food, or shortly thereafter
• PM: Late afternoon with food, or at, or after dinner
• Please see my list of ingredients (below) that I like to see provided by a foundational vitamin and mineral supplement.
• Whenever taking higher doses of vitamin D3, always be sure to increase vitamin K2 intake (at least 180 mcg/day, if not 450 mcg/day).
• Beta glucan supplement derived from Reishi and Shiitake Mushrooms, as well as Baker’s Yeast Extract.
• Liver health supplement that provides numerous ingredients, including N-Acetyl-L-Cysteine (NAC), turmeric extract (curcumin), green tea extract, olive extract, broccoli extract, alpha lipoic acid, milk thistle extract, and biotin.
• Probiotics, at least take 12 billion colony-forming bacteria, providing Lactobacillus rhamnosus LGG® and Bifidobacterium BB12®, every other day or daily.
• When increased doses of vitamin D are taken (> 4000 IU/day, consider increasing vitamin K2 intake by an additional 180 mcg, if not by 450 mcg/day.
• When taking 2000 grams or more of fish oil (omega-3 fatty acids), consider increasing zinc intake (above the 20 mg daily dose already provided in the chelated mineral tablets).  For example, if taking 4 capsules per day of fish oil, consider taking a total of 50 mg/day of zinc.  If taking 6 capsules of fish oil per day, consider taking 50 – 70 mg/day of zinc.  To order additional stand-alone zinc tablets from Douglas Labs by first creating a customer account by CLICKING HERE.  (If this link does not work for you, simply type “douglaslabs.com/patient-account” into a new browser tab.) Please use Referral Code 2074214. Or, call 800-245-4440, let them know you want to set up a Patient Account, and be sure to use Referral Code 2074214.

Ingredients that I like to see provided collectively by vitamin-antioxidant & chelated mineral tablets

Vitamin A, mostly as Beta Carotene
Vitamin C
Vitamin D3
Vitamin E
Vitamin K (K1 & K2)
B-Complex Vitamins
Curcumin (turmeric extract)
Quercetin
Green Tea Extract
Olive Extract
Rutin
Resveratrol
Choline
Lutein
Lycopene
N-Acetyl-L-Cysteine (NAC)
Calcium
Magnesium
Iodine (as potassium iodide)
Zinc
Selenium
Copper
Manganese
Chromium
Molybdenum
Including Ultra Trace Minerals

Ingredients I want to see provided by a “liver support” supplement:

Milk Thistle Extract
N-Acetyl-L-Cysteine
Alpha-Lipoic Acid
Broccoli Extract
Turmeric Extract (Curcumin)
Olive Extract
Green Tea Extract
Biotin

Medical Disclaimer

Information on this website, written, spoken, or in any other communication by Dr. Ladd McNamara or any other information or reference is for informational purposes only. The information provided on this website is a result of years of practice, experience, and study by the author. This information is not intended as a substitute for the advice provided by someone’s personal licensed physician or other healthcare professional, or any information contained on or in any product label or packaging. Do not use the information on this website, or any other form of communication from Dr. Ladd McNamara or the Dr. Ladd VIP Program, for diagnosing or treatment of a health issue or disease, or for the prescribing of medication or the use of supplementation without a discussion with your licensed health professional first.  At best, the information provided on this website is only meant to supplement information provided by your own doctor or health professional, not to replace medical advice.  The information from this website is not meant to cover all possible uses, precautions, interactions or possible adverse effects of nutritional supplements with or without medications, or in conjunction with specific medical conditions.  The information from this website may not fit your specific health circumstances.  Never delay seeking medical care or disregard advice from your health care professional because of information you have received directly or indirectly from this website, from the Dr. Ladd VIP Program, or from Dr. Ladd McNamara himself.   Always speak with your physician or other healthcare professional before making any changes to your medication or embarking on a nutritional, herbal or homeopathic supplement program, or before using any treatment for a health concern. If you have, or suspect that you have, a medical problem, contact your health care provider promptly.  Do not disregard professional medical advice or delay in seeking professional advice because of something you have read or heard on this website, or due to any other information from Dr. Ladd McNamara or his representatives. Information provided on this website or the V.I.P. Program, and the use of any products or services mentioned on this website (or as a result of information provided this program, article, or website) by you DOES NOT create a doctor-patient relationship between you and Ladd McNamara, M.D.  Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

References

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17. Li D, et al.  Effect of grape seed extract on human norovirus GII.4 and murine norovirus 1 in viral suspensions, on stainless steel discs, and in lettuce wash water.  Appl Environ Microbiol. 2012 Nov;78(21):7572-8.
18. Han Y1. Synergic effect of grape seed extract with amphotericin B against disseminated candidiasis due to Candida albicans.  2007 Nov;14(11):733-8.
19. Grace Nirmala J, et al.  Cytotoxicity and apoptotic cell death induced by Vitis vinifera peel and seed extracts in A431 skin cancer cells.  Cytotechnology. 2017 Oct 5. doi: 10.1007/s10616-017-0125-0. [Epub ahead of print]
20. Kumar R, et al.  Procyanidin B2 3,3″-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK.  Mol Carcinog. 2017 Sep 6. doi: 10.1002/mc.22731. [Epub ahead of print]
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26. King M, et al. Oral squamous cell carcinoma proliferative phenotype is modulated by proanthocyanidins: a potential prevention and treatment alternative for oral cancer. BMC Complement Altern Med. 2007 Jun 19;7:22
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